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If it's an outdoor grow I think diseases and fungal infections might be more likely. Try googling "yellow leaf spot Septoria", it's a common fungus that causes yellow spots on leaves.

I sterilized and planted 4 seeds in a couple of in vitro containers, with basic hormone free MS media. Two of them are in an agar media and the other two in a type of autoclaved oasis seed cube stuff. I put some pictures and info in this imgur album: imgur com/a/mhrBF Now to the problem: why...