Can Someone Grow Multiple Plants in a 50 Gallon Container? 2 or more?

The container is 50 gallons and about 2 feet deep by 2 feet wide by 3-4 feet long.

I wanted to know if I put them on opposite sides with a little room from the ends if the plants would have issues such as strangling each other.

Let me know what you think and how many you think could do well in this area. I'd really appreciate it.

Also as a bonus question, if someone had clones that were going to go directly into flowering at 6-8 inches. Could more plants be placed in the same large container.

These are SOIL : ) Thanks!

Of course you can have more than one plant in the same container - especially one of that size. Lots of people do that type of thing, its called "Raised bed" cultivation.
And by the way, the whole "Strangling" thing is a BS myth, they get along just fine together.