Is there any reason why I wouldn't go to 48 plants on a single ebb and grow? Your only limited by your light and grow tray.
I have seen folks with multiple ebb and grows set up with 16 plants each, 24 plants each, but no one seems to want to max it out. I used 4x8 when I was doing Ebb and Flow and grew 50 short dicks at a time, crowding can be an issue.
Is there anything I have to worry about if I take it to the limit?As Harry said be careful about crowding but other than that sky's the limit.
Just an observation from my years of growing; it did not matter how many plants I grew I always came out with the same weight.For example I started with 50 4' cubes than went to 40, 30 and than 24 as I went to less plants I just vegged longer, now I grow 20 plants under 1000w and I am going to go down to 15 and still keep the same yield. I'll just veg a few days longer. Good luck