your first step is always careful consideration of your diet/exercise/sleep schedule with the primary emphasis on diet. You may want to read about the special carbohydrate diet (check "Breaking the Vicious Cycle") as a base reference for why/how people get long term stomach/intestinal problems and why/how people treat them. While it seems that treating any complicated gastro issue is definitely a case by case problem that requires a full body/lifestyle approach, IME a daily regime of probiotic and papaya enzyme help tremendously in creating a more at ease internal gastro-environment. I don't believe anyone should take a PPI long term (prilosec, prevacid,etc. these meds work by blocking acid in the stomach by deactivating the cells responsible for acid production. these cells, however, continue to be produced and lay waiting in a dormant state until one might discontinue using their ppi and then BOOM!!! all stacked up acid cells start producing again and it's off to the hospital) as they are more and more frequently being linked to aggravating the problem and even stomach and bone cancer. my partner has taken one under the direction of her GI for 7 years now (been trying to get off for 3; these pills are not intended for use over 2-3 weeks) and she cant even skip one pill now without causing extreme inflammation and eating problems for weeks (food in throat, intense cramps, nausea). Her specific problems have started to subside after going gluten-free and now she is starting to extract more and more specific carbs from her diet (she might go paleo). This route is specific to her and she is only choosing it after trying and failing with virtually every other approach for 4 years. Again, this is specific to her. We still don't know when she might get off the ppi's. the last time she tried to reduce her dosage it nearly hospitalized her. Sorry to meander so much. I would suggest starting a food journal and when something causes you distress try to identify that food and food group. cheers.A little of the marijuana topic but I too have recently picked up some strange ass stomach issues, bloating, and digestive issues.. I've been looking into probiotics (google and shit) and am seriously thinking about buying some although I don't know anyone personally that takes these are you guys familiar with this? If not its worth checking out.. long story short its friendly bacteria that colonizes in your intestines and takes all the bad bacteria out pretty much, which in theory helps relieve bloating, gas , and is a general health booster especially for people who take a lot of anti-biotics