Dosage wise, if I take 50 of these I'm on top of the world everything is bright with visual traces around everything & make me giggle my head off at anything. They really nice to work with. I've been using them every other day for last cuple of weeks & built up no tollarance of yet. But the best thing is the cum down not a care in the world. They have definitely helped with my depression. It's the best I've felt all year.