RobbieP
Well-Known Member
Get a stolen laptop off agora .... oh you cant get on
The UK Growers Thread!
- Thread starter lozac123
- Start date
shawnybizzle
Well-Known Member
Yehyehyeh fuck agora now bollocks to it all I'll buy more coins n save em
Thc247
Well-Known Member
aint finnished yet got 4 left took 2 days just 2 of us
bazoomer
Well-Known Member
@ Zedd, soz Z , just seen you're post, I'm ok cheers me old muka. My daughters been bad, cancer, had to have some tissue removed & overy, same time as ceserian ! Poor fucker, only 23, not spread, all good atm, cunting kidney stones again, had bad infection , 2 weeks to pass, agony !. Hope you & the family r all good m8. Hello to Rambo 2, and all the crazy bunch 
Garybhoy11
Well-Known Member
Welcome back Baz, soz to hear bout ur troubles man, when shit gets that bad hopefully it can only get better from here on,
Garybhoy11
Well-Known Member
Garybhoy11
Well-Known Member
The commonwealth games closing ceremony after party is still going on in glasgow ,......lol
Garybhoy11
Well-Known Member
Yeah he's fine mate prob just not been on here for a while today, was on earlier tho,
zeddd
Well-Known Member
it does both those things too
zeddd
Well-Known Member
thats not right baz at 23 , get her on high doses of vit c sposed to help, and kdney stones are the only commonly known prob more painful than childbirth so i hope u ok mate thats a bit much to deal with tbh chin up mate@ Zedd, soz Z , just seen you're post, I'm ok cheers me old muka. My daughters been bad, cancer, had to have some tissue removed & overy, same time as ceserian ! Poor fucker, only 23, not spread, all good atm, cunting kidney stones again, had bad infection , 2 weeks to pass, agony !. Hope you & the family r all good m8. Hello to Rambo 2, and all the crazy bunch
R3l@X
Well-Known Member
Saerimmner
Well-Known Member
Morning all
One for you lot..............
Scientists Discover A Novel Mechanism Of Action Of Cannabidiol Against Lung Cancer Cells
August 1, 2014 | by Justine Alford
Photo credit: Martijn, via Flickr. CC BY-SA 2.0
Share36.6K Tweet216 18 Reddit5 16
In recent years, there has been a growing interest in the use of cannabinoids, such as THC and cannabidiol (CBD), as potential anticancer agents. They have yielded promising results in both in vitro (cells in a dish) and in vivo (animal) studies, demonstrating a plethora of antitumor effects such as promoting cell death and decreasing cell migration and invasion. While they may look great on paper, support for their efficacy in clinical settings is lacking as no human cancer trials have so far been published. Furthermore, scientists actually know little about how they exert their effects on cancer cells.
A few weeks ago, light was shed on one mechanism of action thanks to a UK study that identified previously unknown signaling platforms that mediated the anticancer effects of THC. Some are hesitant about using THC, however, given the unwanted psychoactive side effects. CBD may therefore represent a more useful therapeutic agent.
In a recent study, published in Biochemical Pharmacology, scientists set out to unpick CBD’s antitumor properties in the lab. Previous work had found that cannabinoids increase the levels of a sticky protein called intercellular adhesion molecule 1 (ICAM-1) on lung cancer cells which decreases their invasiveness and ability to spread (metastasize). However, how they promote cancer cell death was unknown.
To address this gap in our knowledge, scientists used lung cancer cell lines and cells derived from a lung cancer patient and looked at how CBD-induced ICAM-1 affects adhesion of the cancer cells to killer white blood cells called lymphokine-activated killer (LAK) cells.
The researchers discovered that CBD enhanced the susceptibility of these tumor cells to stick to the LAK cells, subsequently promoting their lysis (destruction). Furthermore, when the researchers blocked ICAM-1 using a neutralizing antibody, the effects of CBD were reversed. Likewise, when the researchers used molecular scissors to chop up ICAM-1 mRNA (the blueprint used to make the ICAM-1 protein), or blocked the cannabinoid receptors that CBD binds to, the compound no longer caused the increase in cancer cell destruction.
The researchers then took this one step further by demonstrating that both THC and an endocannabinoid (a cannabinoid naturally produced by the body) mimic both promoted ICAM-1-dependent tumor cell killing. None of the 3 molecules tested in the study were found to increase the killing of non-tumor cells.
Taken together, these data suggest that the cannabinoid-induced ICAM-1 boost on lung cancer cells is responsible for the increased susceptibility of these cells to destruction by LAK cells. This therefore represents a previously unknown antitumor mechanism of cannabinoids, adding to our knowledge of how these compounds exert their effects on cancer cells in the lab. Whether these effects will be induced in humans with cancer, however, remains unknown.
[Header image "home grown," by Martijn, via Flickr, used in accordance with CC BY-SA 2.0]
Read more at http://www.iflscience.com/health-and-medicine/scientists-discover-novel-mechanism-action-cannabidiol-against-lung-cancer-cells#ibixGV5wDRRFRKET.99
One for you lot..............
Scientists Discover A Novel Mechanism Of Action Of Cannabidiol Against Lung Cancer Cells
August 1, 2014 | by Justine Alford
Photo credit: Martijn, via Flickr. CC BY-SA 2.0
Share36.6K Tweet216 18 Reddit5 16
In recent years, there has been a growing interest in the use of cannabinoids, such as THC and cannabidiol (CBD), as potential anticancer agents. They have yielded promising results in both in vitro (cells in a dish) and in vivo (animal) studies, demonstrating a plethora of antitumor effects such as promoting cell death and decreasing cell migration and invasion. While they may look great on paper, support for their efficacy in clinical settings is lacking as no human cancer trials have so far been published. Furthermore, scientists actually know little about how they exert their effects on cancer cells.
A few weeks ago, light was shed on one mechanism of action thanks to a UK study that identified previously unknown signaling platforms that mediated the anticancer effects of THC. Some are hesitant about using THC, however, given the unwanted psychoactive side effects. CBD may therefore represent a more useful therapeutic agent.
In a recent study, published in Biochemical Pharmacology, scientists set out to unpick CBD’s antitumor properties in the lab. Previous work had found that cannabinoids increase the levels of a sticky protein called intercellular adhesion molecule 1 (ICAM-1) on lung cancer cells which decreases their invasiveness and ability to spread (metastasize). However, how they promote cancer cell death was unknown.
To address this gap in our knowledge, scientists used lung cancer cell lines and cells derived from a lung cancer patient and looked at how CBD-induced ICAM-1 affects adhesion of the cancer cells to killer white blood cells called lymphokine-activated killer (LAK) cells.
The researchers discovered that CBD enhanced the susceptibility of these tumor cells to stick to the LAK cells, subsequently promoting their lysis (destruction). Furthermore, when the researchers blocked ICAM-1 using a neutralizing antibody, the effects of CBD were reversed. Likewise, when the researchers used molecular scissors to chop up ICAM-1 mRNA (the blueprint used to make the ICAM-1 protein), or blocked the cannabinoid receptors that CBD binds to, the compound no longer caused the increase in cancer cell destruction.
The researchers then took this one step further by demonstrating that both THC and an endocannabinoid (a cannabinoid naturally produced by the body) mimic both promoted ICAM-1-dependent tumor cell killing. None of the 3 molecules tested in the study were found to increase the killing of non-tumor cells.
Taken together, these data suggest that the cannabinoid-induced ICAM-1 boost on lung cancer cells is responsible for the increased susceptibility of these cells to destruction by LAK cells. This therefore represents a previously unknown antitumor mechanism of cannabinoids, adding to our knowledge of how these compounds exert their effects on cancer cells in the lab. Whether these effects will be induced in humans with cancer, however, remains unknown.
[Header image "home grown," by Martijn, via Flickr, used in accordance with CC BY-SA 2.0]
Read more at http://www.iflscience.com/health-and-medicine/scientists-discover-novel-mechanism-action-cannabidiol-against-lung-cancer-cells#ibixGV5wDRRFRKET.99
RobbieP
Well-Known Member
Interesting sizzleMorning all
One for you lot..............
Scientists Discover A Novel Mechanism Of Action Of Cannabidiol Against Lung Cancer Cells
August 1, 2014 | by Justine Alford
Photo credit: Martijn, via Flickr. CC BY-SA 2.0
Share36.6K Tweet216 18 Reddit5 16
In recent years, there has been a growing interest in the use of cannabinoids, such as THC and cannabidiol (CBD), as potential anticancer agents. They have yielded promising results in both in vitro (cells in a dish) and in vivo (animal) studies, demonstrating a plethora of antitumor effects such as promoting cell death and decreasing cell migration and invasion. While they may look great on paper, support for their efficacy in clinical settings is lacking as no human cancer trials have so far been published. Furthermore, scientists actually know little about how they exert their effects on cancer cells.
A few weeks ago, light was shed on one mechanism of action thanks to a UK study that identified previously unknown signaling platforms that mediated the anticancer effects of THC. Some are hesitant about using THC, however, given the unwanted psychoactive side effects. CBD may therefore represent a more useful therapeutic agent.
In a recent study, published in Biochemical Pharmacology, scientists set out to unpick CBD’s antitumor properties in the lab. Previous work had found that cannabinoids increase the levels of a sticky protein called intercellular adhesion molecule 1 (ICAM-1) on lung cancer cells which decreases their invasiveness and ability to spread (metastasize). However, how they promote cancer cell death was unknown.
To address this gap in our knowledge, scientists used lung cancer cell lines and cells derived from a lung cancer patient and looked at how CBD-induced ICAM-1 affects adhesion of the cancer cells to killer white blood cells called lymphokine-activated killer (LAK) cells.
The researchers discovered that CBD enhanced the susceptibility of these tumor cells to stick to the LAK cells, subsequently promoting their lysis (destruction). Furthermore, when the researchers blocked ICAM-1 using a neutralizing antibody, the effects of CBD were reversed. Likewise, when the researchers used molecular scissors to chop up ICAM-1 mRNA (the blueprint used to make the ICAM-1 protein), or blocked the cannabinoid receptors that CBD binds to, the compound no longer caused the increase in cancer cell destruction.
The researchers then took this one step further by demonstrating that both THC and an endocannabinoid (a cannabinoid naturally produced by the body) mimic both promoted ICAM-1-dependent tumor cell killing. None of the 3 molecules tested in the study were found to increase the killing of non-tumor cells.
Taken together, these data suggest that the cannabinoid-induced ICAM-1 boost on lung cancer cells is responsible for the increased susceptibility of these cells to destruction by LAK cells. This therefore represents a previously unknown antitumor mechanism of cannabinoids, adding to our knowledge of how these compounds exert their effects on cancer cells in the lab. Whether these effects will be induced in humans with cancer, however, remains unknown.
[Header image "home grown," by Martijn, via Flickr, used in accordance with CC BY-SA 2.0]
Read more at http://www.iflscience.com/health-and-medicine/scientists-discover-novel-mechanism-action-cannabidiol-against-lung-cancer-cells#ibixGV5wDRRFRKET.99
Don Gin and Ton
Well-Known Member
is it actually double zero? does it look blonde or dark? is it from the uk?