Finshaggy
Well-Known Member
I am working on a list, and I am wondering if anyone knows of any natural plants that anyone can find anywhere. Once this list is done, anyone that reads it should be able to find themselves a natural Anti-Depressant or even just mood elevator.
While working on this, I accidentally came across the phrase Oilhuasca. I make my own essential oils from Cinnamon and Lemon Peel and Peppermint leaf and all that, and I have been wanting to do some "Pihkal" and "Tihkal" type smell research. So when I was researching plants that activate these receptors, and found the phrase "Oilhuasca" a whole new landscape opened up in front of me. I AM NOT CLAIMING TO BE AN OILAHUASCA EXPERT, DO YOUR OWN RESEARCH AFTER READING.
I recently found out that Bitter Orange extract is like Norepinephrine, which really made me second think for a second. I knew Ephedra contained Ephedra which is used to make meth, but that never interested me. And I also knew that MDA/MDMA could be make from Black Pepper or Sassafras, but I don't want to be an ecstasy cook.
And I have known about Entheogens, everything from San Pedro, to Datura to Amanita or Marijuana and Betel. I have read about almost everything and have tried a few things. But these are always classified as "Psychedelic" or "Stimulant" or "Sedative". And most of the stuff people are looking for are "Opiate Replacements" or "Marijuana Replacements" and I am not really interested in Opium, or replacing Marijuana.
So, we know of plants that contain DMT, and LSA and Mescaline, but we don't really pay attention to the plants that act on those SAME receptors, just in a lighter way. So, why not do that now?
I can hardly find anything about this stuff online, but some people have posted some stuff and here is what I can find.
Graviola- 5-HT1a Agonist
Black Cohosh- 5-HT1A, 5-HT1D & 5-HT7 Binding
C. Foetida L.- 5-HT1A Agonist
Yokukansan- 5-HT1A Agonist
DMT hits ALL of these, and can be found in tons of plants.
If anyone can find something that binds/agonizes the 5-HT1B receptor, please post it. All I can find that is not a prescription is TFMPP, but that is not from a plant. There are also "Triptans" but they are also not natural.
I can't find anything that goes to the 5-HT1D receptor except black Cohosh.
St. John's Wort should be on here, I just can't find out where. And 5-HTP, L-Theanine and L-Tryprophan can help also, but I am not sure if they are specific in their action. Kanna should be on here, but I don't know exactly where. And maybe Rhodiola rosea, Albizia lebbeck & Albizia julibrissin.
I read some where that these are 5-HT1 Receptor Agonists:
Turmeric, Ginger, Ginko Bilboa, Lemon Essential Oil, Rauwolfia, Valerian, Yohimbe
(also from what I have read)
Elmicin & Myristicin (in Nutmeg)- 5-HT2A Agonist
Estragole (in Sweet Basil)- 5-HT2A Agonist
Safrole (in Sassafras)- 5-HT2A Agonist
Those 4 oils are the main oils used in Oilahuasca, please name more if you know them. They say they can be taken by swallowing, huffing or rubbing it on your skin.
Some people report Black Pepper being of use by adding Peperidine to the body, some claim black pepper made things weaker. Just thought I would add that here. Making Pepper tea with water and filtering out the solids can help keep the good stuff in and keep the bad stuff out they say. And Synephrine might do something with the pepper. Also, L-Lysine can be used instead of pepper.
These next oils are the oils you need to activate them.
Cinnamon Bark- CYP2A6 & CYP2E1 Inhibitor (It will deplete your liver's Glutithione) Taken 1 Hour before Allybenzene,
Clove Leaf- CYP2C9, CYP3A4, CYP1A1 & CYP1B1 Inhibitor
German Chamomile- CYP1A2 Inhibitor (Caffeine may also do this)
Also
GoldenSseal & Echinacea purpurea very effectively do the same thing. And people have reported using Vitamin B9 or Almond extract or Star Anise Extract and Tangerine Peels or Extract.
And from what I am finding now, Black seed oil, 50% EGCG, Valerian root oil, Pomegranate, Vitamin B9, 40% Ellagic extract, Rooibos 20% Gallic acid extract, Rutin, B3 & Kudzu are best here. THC is also said to have an effect here.
I have read something about DMSO being used with these, not exactly sure on this though.
This supposedly only leaves a few enzymes to break things down, rendering these things orally active. They may not work for everyone, and dosage is unsure at this point. But people have reported better results with Phenethylamine (Some people say you NEED to take it with your Allylbenzene, or at least some kind of 'amine' like Tryptamine) and Phenelalanine. As well as Coffee and Cayenne Pepper. Milk may also do something, it contains a few things like Tryptophan and Choline.
The 4 Oils listed are "AllylBenzenes", here is a larger list, but I am not sure if anyone has ever tried to Oilahuasca these yet, and I do not know if it is safe, so I am not suggesting anyone try these, they are just here for the sake of discussing them so people in the future can be safe.
Anethole, Apiol, Asarone, Carpacin, Chavibetol, Chavicol, Dillapiole, Eugenol, Isoeugenol, Isosafrole, Methyl Eugenol, Methyl Isoeugenol,
And since Cinnamon is a Phenylpropanoid, and Phenylpropanoids are made from Phenelalamine, and people who took Phenelalamine claim to get better results. I decided to post a list of Phenylpropanoids also.
Caffeyl Alcohol, Cinnamaldehyde, Cinnamyl alcohol, alpha-Cyno-4-hydroxycinnamic acid, Ethyl Cinnamate, Lignin, 2,4-Methlenedioxypropiophenone, Neoflavonoids, Nordihydroguaiaretic acid, Phenylpropanoic acid, Phloretic acid, Rhododendrin & Suberin.
Here are the things that you need to make sure the Oil works.
Star Anise Extract or B9 for CYP2C9 Induction
Most important things:
CYP2C9 Induction
Alcohol Dehydrogenase Induction
Aldehyde Dehydrogenase Inhibition
Piperidine and or Dimethylamine Supplementation
Methyl from foods
Exercise or compounds that produce effects like exercise
Less important, but still factors:
SSAO Inhibition (Caffeine, Phenethylamine, Phenelalamine, Tryptamine)
MAO-A Induction
MAO-B Induction
NDMA Antagonism
Prolactin Inhibition
Here are some Piperadines (Pepper Replacement)
Thioridazine, Haloperidol, Mesoridazine, Raloxifene, Loperamide, Risperidone & Paroxetine
Peppermint oil has also been talked about as a possible base instead of the Allylbenzenes.
And there is an Oilhuasca diet you are supposed to keep up for a day or so before the Oilahusca, because some foods naturally counteract these effects you are looking for. If you take lots of Vitamins and stuff too, some of those could get in the way. If you look up "Oilahuasca Diet" you can find it.
No one seems to have mentioned this, but MAOIs could help in this also. But do not eat Chocolate, Cheese or Alcohol if you take MAOIs.
While working on this, I accidentally came across the phrase Oilhuasca. I make my own essential oils from Cinnamon and Lemon Peel and Peppermint leaf and all that, and I have been wanting to do some "Pihkal" and "Tihkal" type smell research. So when I was researching plants that activate these receptors, and found the phrase "Oilhuasca" a whole new landscape opened up in front of me. I AM NOT CLAIMING TO BE AN OILAHUASCA EXPERT, DO YOUR OWN RESEARCH AFTER READING.
I recently found out that Bitter Orange extract is like Norepinephrine, which really made me second think for a second. I knew Ephedra contained Ephedra which is used to make meth, but that never interested me. And I also knew that MDA/MDMA could be make from Black Pepper or Sassafras, but I don't want to be an ecstasy cook.
And I have known about Entheogens, everything from San Pedro, to Datura to Amanita or Marijuana and Betel. I have read about almost everything and have tried a few things. But these are always classified as "Psychedelic" or "Stimulant" or "Sedative". And most of the stuff people are looking for are "Opiate Replacements" or "Marijuana Replacements" and I am not really interested in Opium, or replacing Marijuana.
So, we know of plants that contain DMT, and LSA and Mescaline, but we don't really pay attention to the plants that act on those SAME receptors, just in a lighter way. So, why not do that now?
I can hardly find anything about this stuff online, but some people have posted some stuff and here is what I can find.
Graviola- 5-HT1a Agonist
Black Cohosh- 5-HT1A, 5-HT1D & 5-HT7 Binding
C. Foetida L.- 5-HT1A Agonist
Yokukansan- 5-HT1A Agonist
DMT hits ALL of these, and can be found in tons of plants.
If anyone can find something that binds/agonizes the 5-HT1B receptor, please post it. All I can find that is not a prescription is TFMPP, but that is not from a plant. There are also "Triptans" but they are also not natural.
I can't find anything that goes to the 5-HT1D receptor except black Cohosh.
St. John's Wort should be on here, I just can't find out where. And 5-HTP, L-Theanine and L-Tryprophan can help also, but I am not sure if they are specific in their action. Kanna should be on here, but I don't know exactly where. And maybe Rhodiola rosea, Albizia lebbeck & Albizia julibrissin.
I read some where that these are 5-HT1 Receptor Agonists:
Turmeric, Ginger, Ginko Bilboa, Lemon Essential Oil, Rauwolfia, Valerian, Yohimbe
(also from what I have read)
Elmicin & Myristicin (in Nutmeg)- 5-HT2A Agonist
Estragole (in Sweet Basil)- 5-HT2A Agonist
Safrole (in Sassafras)- 5-HT2A Agonist
Those 4 oils are the main oils used in Oilahuasca, please name more if you know them. They say they can be taken by swallowing, huffing or rubbing it on your skin.
Some people report Black Pepper being of use by adding Peperidine to the body, some claim black pepper made things weaker. Just thought I would add that here. Making Pepper tea with water and filtering out the solids can help keep the good stuff in and keep the bad stuff out they say. And Synephrine might do something with the pepper. Also, L-Lysine can be used instead of pepper.
These next oils are the oils you need to activate them.
Cinnamon Bark- CYP2A6 & CYP2E1 Inhibitor (It will deplete your liver's Glutithione) Taken 1 Hour before Allybenzene,
Clove Leaf- CYP2C9, CYP3A4, CYP1A1 & CYP1B1 Inhibitor
German Chamomile- CYP1A2 Inhibitor (Caffeine may also do this)
Also
GoldenSseal & Echinacea purpurea very effectively do the same thing. And people have reported using Vitamin B9 or Almond extract or Star Anise Extract and Tangerine Peels or Extract.
And from what I am finding now, Black seed oil, 50% EGCG, Valerian root oil, Pomegranate, Vitamin B9, 40% Ellagic extract, Rooibos 20% Gallic acid extract, Rutin, B3 & Kudzu are best here. THC is also said to have an effect here.
I have read something about DMSO being used with these, not exactly sure on this though.
This supposedly only leaves a few enzymes to break things down, rendering these things orally active. They may not work for everyone, and dosage is unsure at this point. But people have reported better results with Phenethylamine (Some people say you NEED to take it with your Allylbenzene, or at least some kind of 'amine' like Tryptamine) and Phenelalanine. As well as Coffee and Cayenne Pepper. Milk may also do something, it contains a few things like Tryptophan and Choline.
The 4 Oils listed are "AllylBenzenes", here is a larger list, but I am not sure if anyone has ever tried to Oilahuasca these yet, and I do not know if it is safe, so I am not suggesting anyone try these, they are just here for the sake of discussing them so people in the future can be safe.
Anethole, Apiol, Asarone, Carpacin, Chavibetol, Chavicol, Dillapiole, Eugenol, Isoeugenol, Isosafrole, Methyl Eugenol, Methyl Isoeugenol,
And since Cinnamon is a Phenylpropanoid, and Phenylpropanoids are made from Phenelalamine, and people who took Phenelalamine claim to get better results. I decided to post a list of Phenylpropanoids also.
Caffeyl Alcohol, Cinnamaldehyde, Cinnamyl alcohol, alpha-Cyno-4-hydroxycinnamic acid, Ethyl Cinnamate, Lignin, 2,4-Methlenedioxypropiophenone, Neoflavonoids, Nordihydroguaiaretic acid, Phenylpropanoic acid, Phloretic acid, Rhododendrin & Suberin.
Here are the things that you need to make sure the Oil works.
Star Anise Extract or B9 for CYP2C9 Induction
Most important things:
CYP2C9 Induction
Alcohol Dehydrogenase Induction
Aldehyde Dehydrogenase Inhibition
Piperidine and or Dimethylamine Supplementation
Methyl from foods
Exercise or compounds that produce effects like exercise
Less important, but still factors:
SSAO Inhibition (Caffeine, Phenethylamine, Phenelalamine, Tryptamine)
MAO-A Induction
MAO-B Induction
NDMA Antagonism
Prolactin Inhibition
Here are some Piperadines (Pepper Replacement)
Thioridazine, Haloperidol, Mesoridazine, Raloxifene, Loperamide, Risperidone & Paroxetine
Peppermint oil has also been talked about as a possible base instead of the Allylbenzenes.
And there is an Oilhuasca diet you are supposed to keep up for a day or so before the Oilahusca, because some foods naturally counteract these effects you are looking for. If you take lots of Vitamins and stuff too, some of those could get in the way. If you look up "Oilahuasca Diet" you can find it.
No one seems to have mentioned this, but MAOIs could help in this also. But do not eat Chocolate, Cheese or Alcohol if you take MAOIs.
