Yes, the ventilation for the lights should be its own separate circuit independent of the rooms ventilation/cooling . If you can pull from one area and dump it to another, that'd be better as you won't be recirculating the hot air.
I'd run 2 intakes, 1 exhaust. Something like:
8" intake>flex duct>8"cooltube>8"cooltube>flex duct>
......................................................................................... >8"×8"×10" "Y"duct>10"fan>outside
8" intake>flex duct>8"cooltube>8"cooltube>flex duct>
Then close up any room vents, except for the AC exhaust, and see how it does.
4 plants per light x 4 lights x 4ozs ea(min. I'd hope) = 4 lbs. That's what I'd be shooting for at the low end, although I'm usually around 6ozs per plant growing 4 per 600, so that'd be closer to 6lbs, if you can control the environment.