without looking i think 150s are 16000 lumens, so the 250 would have more lumens in 1 spot and a little better penetration but i dont think it would out way the spread you could get from the 2 150s. I would go with a lower lumen spread more than a higher lumen in 1 spot. 42w cfls are inly like 2600 lumens or something and those can frow nice sized dense buds, so i would focus more on coverage than intensity.