purity is the problem nowadays. take ecstasy as an example. what we can buy now is nowhere near the quality of what we were able to buy 10-15 years ago. MDMA in those pills has been reduced to minimum because replacing it with speed, meth and strychnine is cheaper and easier for whoever produces those.
And the problem is it still sells because some kids will take whatever gets them high from local dealer.
Most of the powders are so badly cut with other stuff this days that you are not actually sure what are you snorting.
As to those newly available compounds - how do you know it has been made in clean laboratory and not by some idiots who after reading some books on the subject decided to make some money so they bought some chemicals plus couple of buckets and started production in their garage hoping for the best.
i am not against those substances in general - problem is purity and i am not reccomending it because it can do so much harm.
i know human made chemicals can be soooo mind blowing (i am a big fan of Alexander Shulgin work) but because there is so many people trying to rip us off it is soo hard to find decent stuff today
