Question about the potency of marijuana... slightly confused here

smellzlikeskunkyum

Well-Known Member
see why i said lets give the THC arguement a rest? this doesnt belong in a seed/strain review thread anyways i suppose if u wanna get technical.

there is just too much gray area for anyone to be making any hard set claims on what is what when it comes to what exactly gets u high and everything.

u can have two seperate strains that test EXACTLY the same(or close to it) in THC and CBD's. I bet those strains will STILL give you two entirely different highs, especially if one is sativa and the other is indica. no matter how exact same the CBD is in either...
 

Rare D MI

New Member
A huge factor in the quality and characteristics of the high is the terpenoid profile. Terpenes have their own set effects they have when used alone. The high we get is what is classified an "entourage" effect. It's the sum of all of its parts. THC, CBD, CBN, etc. levels give us a general idea of medicinal potential or "strength" but it's the terpenes present that really determine the overall enjoyability, effectiveness, and quality of high.
 

smellzlikeskunkyum

Well-Known Member
A huge factor in the quality and characteristics of the high is the terpenoid profile. Terpenes have their own set effects they have when used alone. The high we get is what is classified an "entourage" effect. It's the sum of all of its parts. THC, CBD, CBN, etc. levels give us a general idea of medicinal potential or "strength" but it's the terpenes present that really determine the overall enjoyability, effectiveness, and quality of high.
I agree. perhaps thats why it seems every plant in veg that has a heavy stench, tends to be a high hash ratio plant, or at least high potency.

i have a High times Medical Marijuana mag from summer 2012. they talk about the terpenes and show what they are exactly in a few strains they test. they also compare the turpenes to other non-weed things that also have the same turpenes.
they discuss how the turpenes can be specifically used for certain things. its a good read.
 

kermit2692

Well-Known Member
hey interesting topic regardless of the fact that its not down to an exact science... my opinions arent set in stone so its good to get other opinions on the subject...only way to gain knowledge! i agree that alot more comes into play than thc i just wish their was a better way to calculate and evaluate these numbers...
 

smellzlikeskunkyum

Well-Known Member
here are pics of the two white rhino phenos i have like i promisedDSCF0163.jpg
DSCF0166.jpgDSCF0164.jpg
the sour is the smaller one with two main branches. the spicey/sweet one is the multi-top one that looks a tad scraggly atm.
 

Jogro

Well-Known Member
good post for the most part. the last part is wrong tho.

sativas can have VERY high CBD's. it DOESNT make them stoney/couchlock. New sativa CBD hybrids are poppin up all over. just saying.
If you want to parse this specifically, in fact, most drug strains that people call "sativas" aren't really.

They're hybrids of tropical or subtropical 'sativa' strains and subcontinental 'indica' strains. Many of these are so polyhybridized, that the whole concept of sativa/indica is dubious. They should probably be called "modern hybrid drug strains" and left at that.

Anyway, sure there are modern hybrids with sativa traits that have CBD in them, but so far as I know, there aren't any true (ie landrace) "sativa" plants that have significant CBD content.

In terms of "couchlock" CBD actually acts to inhibit the effect of THC. Paradoxically, strains that have REALLY high CBD lose most of their psychoactive effect.

As mentioned, there are several dozen other cannabinoids that potentially modulate the effects of THC as well, and for most of them, nobody really knows exactly what they do, except that by themselves they won't get you "high". Certain terpenes (eg myrcene) probably do play a role in affecting transport of cannabinoids across the blood-brain barrier, and may have other effects including affecting high quality, though I think at this point how exactly they interact with other cannabinoids and how important they are is still debatable.

THCV, mentioned above, can be found in some strains and has a more psychedelic effect. IIRC, it can also be created by the liver from ingested "ordinary" THC, largely explaining why eating cannabis provides a qualitatively different and much more "trippy" effect than smoking it.

CBD is not a deciding factor in seperating indica from sativa.
Agree; see above. At best its one factor.

Note that from a pure taxonomic standpoint all cannabis plants are "cannabis sativa" (even indicas, hemp, and ruderalis), since they are all of the same species and can interbreed.
 

Jogro

Well-Known Member
there is just too much gray area for anyone to be making any hard set claims on what is what when it comes to what exactly gets u high and everything.
Well, there are several decades worth of peer-reviewed published research on cannabinoids looking at this very question of what exactly gets you "high", not to mention several thousands of years of cumulative human experience.

While there are still questions about some of the lesser cannabinoids, and especially secondary molecules like terpenes and alkaloids, at this point, its no longer a mystery which exact molecules cause the major effects.

u can have two seperate strains that test EXACTLY the same(or close to it) in THC and CBD's. I bet those strains will STILL give you two entirely different highs, especially if one is sativa and the other is indica. no matter how exact same the CBD is in either...
Going to first principles, cannabis is still a drug (or mixture of drugs) and all the normal principles of pharmacology that apply to every other drug apply to cannabis too.

Again, there is more to it than just THC and CBD, though those two are by far the two most important molecules in most strains/samples and together probably account for the majority of subjective effect.

Ultimately, if you have two different samples (or strains) with similar chemical profiles they're going to have similar effects, just by simple pharmacology. They can't be "entirely" different. The question, really, is how much do the minor cannabinoids matter, and how much do other compounds (eg terpenoids and alkaloids) matter.

On minor cannabinoids, I think THCV matters, if you have it. The others (CBG, CBN, CBC, etc), also have some effect though how much is debatable and maybe subjective.

On terpenes (and alkaloids, which haven't been mentioned here), that's complicated, because there are so many different ones.

Most of them have no pharmacologic effect whatsoever. Several of them do have documented medical effects all on their own (not necessarily psychoactive ones) but the effects are relatively mild. A few of these have been shown to potentiate cannabinoids crossing the blood brain barrier even act as partial cannabinoid receptor agonists on their own (eg, myrcene).

But again, I think there is still plenty of room for debate on how important these things really are. I don't doubt that these things potentially have some relevant effects but personally I take claims that these things act as major determinants of "high" quality with a pretty big grain of salt, especially considering just how little of these substances there is by mass inside the buds. "Smell level" chemicals aren't going to do anything in a pharmacologic sense.

If particular terpenes were really linked with specific effects on high quality, I'd think that would be common knowledge, just by empirical experience. For example, some people have claimed that eating mangoes for their myrcene prior to smoking will intensify the high, but I haven't seen any real evidence that this is true. If you could get "high" by cannabinoid agonist action by myrcene alone, people would be getting high just by eating mangoes (or whichever other plant had agonist terpenes). . .again, don't think this is the case.
 

Jogro

Well-Known Member
A huge factor in the quality and characteristics of the high is the terpenoid profile. Terpenes have their own set effects they have when used alone. The high we get is what is classified an "entourage" effect. It's the sum of all of its parts. THC, CBD, CBN, etc. levels give us a general idea of medicinal potential or "strength" but it's the terpenes present that really determine the overall enjoyability, effectiveness, and quality of high.
You say this, and no offense intended, but is there actual evidence that its true?

The biggest proponent of this idea, the one who coined the term "entourage effect" is EB Russo, a clinical neurologist and well-known figure in medical cannabis research. I've read over some of his literature, and I have yet to see to see him actually make the claim that terpenes are "the" major determinant of high quality, let alone even "a" major determinant.

He does believe there may be SOME pharmacologic effects, but most of the ones he describes aren't related to "high" and many of these are still speculative (note the "if proven" language in his recent abstract, below):

This may be a bit technical for some, but a really good summary is here, going into depth about what these molecules are, with some evidence of what they do:
http://cannabisclinicians.org/wp-content/uploads/2011/09/Russo-Entourage-Effect.pdf

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
Russo EB.
Source
GW Pharmaceuticals, Salisbury, Wiltshire, UK. ethanrusso@comcast.net
Abstract

Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia have been scientifically demonstrated. Other phytocannabinoids, including tetrahydrocannabivarin, cannabigerol and cannabichromene, exert additional effects of therapeutic interest. Innovative conventional plant breeding has yielded cannabis chemotypes expressing high titres of each component for future study. This review will explore another echelon of phytotherapeutic agents, the cannabis terpenoids: limonene, myrcene, α-pinene, linalool, β-caryophyllene, caryophyllene oxide, nerolidol and phytol. Terpenoids share a precursor with phytocannabinoids, and are all flavour and fragrance components common to human diets that have been designated Generally Recognized as Safe by the US Food and Drug Administration and other regulatory agencies. Terpenoids are quite potent, and affect animal and even human behaviour when inhaled from ambient air at serum levels in the single digits ng·mL(-1) . They display unique therapeutic effects that may contribute meaningfully to the entourage effects of cannabis-based medicinal extracts. Particular focus will be placed on phytocannabinoid-terpenoid interactions that could produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections (including methicillin-resistant Staphylococcus aureus). Scientific evidence is presented for non-cannabinoid plant components as putative antidotes to intoxicating effects of THC that could increase its therapeutic index. Methods for investigating entourage effects in future experiments will be proposed. Phytocannabinoid-terpenoid synergy, if proven, increases the likelihood that an extensive pipeline of new therapeutic products is possible from this venerable plant. http://dx.doi.org/10.1111/bph.2011.163.issue-7.
 
Maybe it's sort of like 90 proof alcahol. Which is like saying it's 45% alcahol...

Or whatever % THC you want. More of sort of an indication of composition. Rather then an exact figure of structure.
 

Rare D MI

New Member
You say this, and no offense intended, but is there actual evidence that its true?

The biggest proponent of this idea, the one who coined the term "entourage effect" is EB Russo, a clinical neurologist and well-known figure in medical cannabis research. I've read over some of his literature, and I have yet to see to see him actually make the claim that terpenes are "the" major determinant of high quality, let alone even "a" major determinant.

He does believe there may be SOME pharmacologic effects, but most of the ones he describes aren't related to "high" and many of these are still speculative (note the "if proven" language in his recent abstract, below):

This may be a bit technical for some, but a really good summary is here, going into depth about what these molecules are, with some evidence of what they do:
http://cannabisclinicians.org/wp-content/uploads/2011/09/Russo-Entourage-Effect.pdf

Do you have experience smoking herb and having it tested?
I have smoked well grown, pleasant tasting and smelling herb that got me pretty high. Figured it was about average or a bit high on the THC level. I had it tested and it hit 11.8% THC. That is the only strain I have ever had test below 15%, but it still gets me just as high as some herb that was less flavorful but tested at 15.5% THC, in fact I enjoyed the high more of the "weaker" strain.

So I base my opinion on results I have seen and having talked extensively to breeders like DJ short who has a breakdown of every single strain he has and the terpenes in each one, and then he had the terpenes/waxes separated from the other cannabinoids and tested via GC/MS.

He then keeps samples of both separate and takes them around to show people. These are co2 extracts by the way... Guess what, pure THC or cbd aren't enjoyable. The terpenes alone aren't medicinal. Put them together, you have an entourage effect.

Don't be the person doubting the world is round, or the earth revolves around the sun... These things will be proven with time.
 

Jogro

Well-Known Member
I have smoked well grown, pleasant tasting and smelling herb that got me pretty high. Figured it was about average or a bit high on the THC level. I had it tested and it hit 11.8% THC. That is the only strain I have ever had test below 15%, but it still gets me just as high as some herb that was less flavorful but tested at 15.5% THC, in fact I enjoyed the high more of the "weaker" strain.
I've had this experience too (liking "weaker" cannabis more), and of course buds can have subjectively different effects, irrespective of just THC content.

Again, with respect to "high" quality, other non-THC cannabinoids matter, dosing matters, and so do subjective factors including tolerance (which may be variable between different cannabinoids), mood, expectation, and even seemingly unrelated things like full/empty stomach (since this may affect the rate of hepatic cannabinoid metabolism via portal blood flow).

The question isn't whether 12% THC buds can get you just as "high" as 16% buds, and its not even whether "high" quality can be better with lower THC strains. I don't really think there are any experienced smokers who doubt either of these two things. Everyone also agrees that terpenoids are the agents primarily responsible for the various smells and flavors of cannabis strains, and that these things do provide at least a significant part of the subjective pleasure of smoking. So absolutely terpenes "matter".

You made the pretty striking claim that terpenoids are also the single major determining factor in pharmacologic "high" quality. So far as I can tell, nobody else is making that specific claim, that's why I asked you about it.

So I base my opinion on results I have seen and having talked extensively to breeders like DJ short who has a breakdown of every single strain he has and the terpenes in each one, and then he had the terpenes/waxes separated from the other cannabinoids and tested via GC/MS. He then keeps samples of both separate and takes them around to show people. These are co2 extracts by the way...
OK, that's fair.

Is DJ Short actually making the claim that *the* major determinant of subjective high quality is terpenoid content?

FWIW, Greenhouse ceeds also publishes terpene numbers for all of their strains, though I don't think they're making this sort of claim (yet).

Guess what, pure THC or cbd aren't enjoyable. The terpenes alone aren't medicinal. Put them together, you have an entourage effect.
Well, I agree that pure CBD doesn't cause a "high" and isn't by itself enjoyable.

Whether or not pure THC is "enjoyable" is subjective. Because pure THC can cause a "speedy" effect with lots of side effects (racing heart, panic, dry mouth, etc), I think many smokers do prefer some modulating agents too (like CBD) mixed into their smoke. But pure THC most certainly does cause a "high" and there definitely are individuals who enjoy it.

You don't have to take my word for it. There is quite a body of published scientific literature indicating that yes, pure THC will get you "high". (EG http://www.ncbi.nlm.nih.gov/pubmed/16148455 for a relatively recent one ).

On terpenes "alone" being medicinal, there is also quite a bit of research on individual compounds, and some of these probably do have medically useful effects, though most of the documented effects are unrelated to getting "high".

Again, the scientist who invented the term "entourage effect" did so at least in part to draw attention to the effects of the so called "minor" cannabinoids: CBD, THCV, CBG, and CBC. He is probably the world's leading expert in the area of terpene/cannabinoid interactions. Yes, he claims that terpenes are part of the "entourage", but even he's saying its an open question as to what most of these actually do in human smokers, with a lot of this being speculative.

To the point, with the exception of myrcene (which he claims may contribute to "couchlock") so far as I can tell, he's not making claims that terpenes play a major role in psychoactivity. He does speculate that some terpenes may modulate certain effects associated with other cannabinoids, but without good clinical evidence. If you care to read his entire piece, you can do so for free here. Its an excellent summary, though it may be a bit of a tough "read" if you're not familiar with medical/pharmacologic jargon. The references he cites are also good too:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

Don't be the person doubting the world is round, or the earth revolves around the sun... These things will be proven with time.
With due respect, likening others who disagree with you of being "flat earthers" is a tactic used by people who don't have the facts on their side.

If you have evidence that supports your position, cite it.

Its perfectly fine to believe things without proof, but if you don't have evidence that supports your beliefs, the intellectually honest thing to do is just to say so.

Again, I'm perfectly willing to believe that terpenes have medical effects, and even that some of them might affect high quality to some degree. But I'm not ready to accept that these things are "the" major factor explaining subjective differences without a good bit more evidence than I've yet seen.
 

donniemcm

Well-Known Member
I'm thoroughly enjoying all of this information!!!!!!!!! Very interesting to see what I considered to be a somewhat basic question blossom into something much more intricate than I ever imagined!!! SO many factors I was never aware of~ TY ALL for taking the time to post!!
 

Rare D MI

New Member
Do you know anything about essential oils and aromatherapy? All based on specific terpenoids having therapeutic and soothing/healing properties. Terpenes being beneficial medicinally is not a new concept unique to cannabis.

Do you actually have experience with these things or have you just read a lot on the Internet? Mentioning greenhouse seeds in this convo doesn't help your case. DJ short isn't using his info as a marketing tool like greenhouse. His is personal information he keeps with him and it is all of his strains he has grown, tested over a 6 year period to see changes in the cannabinoid and terpene profiles over a long cure period. It is specifically for the purpose of pinpointing exactly what is present in what's he considers to be the best medicine he grows. He lab work is done at the werks in Seattle.

and no I don't have evidence to cite, due to the illegality of cannabis federally, there aren't many places allowed to study these things... So you knew I couldn't cite it, so why bother asking? Also I'm very busy, I don't exactly have time to scour the Internet to post links for you, to back up something I believe to be true. It is of little consequence whether you believe me or not.
 

althor

Well-Known Member
Let me put it like this....

Hash has the highest percentage of thc I have sampled.
I dont care for hash at all. Higher THC does not mean a better buzz in my opinion.
Hash/oil gets me high as hell (not even what I consider a enjoyable buzz) for about 15 minutes.
 

kermit2692

Well-Known Member
so the ultimate question is how much of each what is exactly ideal for the perfect nug lol....and we just arent going to get that answer anytime soon...fun to speculate and take in everyones ideas though..the ideal thing to do to find this info would be to find the best smoke test it find a strain with high thc and test it continue to test samples until you can evaluate what exact combo is the most enjoyable to the majority of people...now that is a serious undertaking though
 

str8sativa

Well-Known Member
DSC00534.jpg (white fire og) stay away from green house. white rhino is a good strain but theirs is definitely not real. and just because someone can pull 20%+ with a strain doesn't mean you can so dont believe the thc hype that everyone is claiming. get whitefire og or white strawberry cough from og raskal all his strains are insane
 

ThE sAtIvA hIgH

Well-Known Member
yeah i know its a hit or miss thing... one of the best strains ive ever grown high-wise has been Nirvana's chrystal. and one of the strongest ive ever smoked period,but not grown myself, was Nirvana's Raspberry Cough. and Nirvana gets bashed BIG time on these boards... i hear it all the time.

I have two different phenotypes of their White Rhino just switched to flower. ask away if u want... one of the pheno's has been grown a ton of times already.
see this is why i dont trust seed banks, coz i grew nirvanas chrystal and it was the worst strain ive ever touched by along way .
 
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