Follow the directions on the bottle. It's a very safe product. I have used it at twice the 'aggressive' strength and it didn't hurt my plants. If you have no current disease problems and you res stays around 70f or below, then use the 'light' strength. If you res is 70-75f use the medium strength. If you currently have root problems, use aggressive until they go away.
Zone can not be used with organics or beneficial microbes.