There's lots of info on this stuff already...But since I use Azamax personally il chime in....I use it as a preventative measure, as I'm sure you know it's not a kill on contact but an antifeedent. I like to alternate between cold pressed neem and Azamax ....However the last few years I've just mixed the Azamax as directed and added neem with a little dish soap ...I mist my plants with this mix about every 14 days during vegg....I stop all sprays once flowering is in full swing, wether they they say spray up until harvest or not .....I personally like azamax, it's pricey but a little goes a long ways. It has worked awesome for preventative maintenance on my plants ....