If you dont have a tolerance-no your equilibrium will be outa there and youll quickly be falling or spinning into your nearest toilet.
Good combos are weed and dxm as it turns thc into a full agonist. A con is that it will kill your tolerance and consult if on any other medications. any hallucinogen or dissociative. benzos though youll realize after you hit some herb you lose your memory as they both hit gabba. This will cause flashes in your memory the next day about 2hrs. You will also burn through alot more weed than normal. opiates, in combination will increase dehydration and constipation, also a heavier nod. Otherwise a good combo. Cocaine can be unpleasant when mixed for many, anxiety, parnoia etc.
My 2 pennies