i recently decided to take the dome off a clone (i use a clear plastic cup for the dome). It got yellow and wilted within 2 hours. smaller leaves were really dry. popped the dome back and it grew a frickin mohawk. none of my domed clones had any mold at all. the affected one is limping along, but i dont expect it to make it. kept her for curiosity more than anything.
My point here is that clones within domes seem sensitive to rapid humidity changes like that. if it's not rooted yet, it could die very quickly. i wait till the roots go crazy or the plant doesnt fit in its individual dome anymore...