Really depends on how strong your chemistry is. Cannabis thrives with the base nutrients N-P-K (Nitrogen, Phosphorus, Potassium). So in theory if you could find pure substances containing those elements and you know how to properly portion them id say go for it. But IMO i think it is only worth it to make your own if you can do it in mass quantities. But unless you have a ILLEGAL 200+ plant op. cant see the need.