I believe the label on serenade says that it can be applied up to the day of harvest, but it stinks and I do not find it too terribly effective. Milk also can be applied up to the day of harvest but can also get to be stinky also, and I'm not very happy with the results of that either. Obviously you must let the buds dry out or you will have bigger problems than just p.m. The best way to deal with p.m is to avoid getting it in the first place wich is also easier said than done.