I started misting before I even knew anything about growing. It did no harm to my last plant, some of the fan leaves were very large and I decided to look up some info on spraying the leaves. What I read, was the plant as the leaves dry out produces more resin to protect the plant, so misting all the time causes the plant to not need to produce as much resin as it could. Now, I did this on my last plant and it turned out really nice and is strong, but on this plant that is almost finished it also looks very good and never misted it. So, I would say either way your ok, might get minor burn spots if using a hps or mh but otherwise won't do much harm or help much and whatever you do, don't mist with a hps where water can hit the bulb and blow up.