Pandemic 2020

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injinji

injinji

Well-Known Member
TacoMac said:
Anybody with a brain knew it was here weeks ago. There have been non stop incoming flights from India up until yesterday.

Trust me, that variant is all over the U.S. right now.
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Two weeks ago it was in three states. Last week in six. So. . . . . . .
 
DIY-HP-LED

DIY-HP-LED

Well-Known Member
This can explain a lot and perhaps some of the temporary effects of the vaccines. It also demonstrates that those who won't get vaccinated are playing with fire and long term maiming. Covid can screw you for live and this is one of the ways it does it.
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COVID-19 Is a Vascular Disease: Coronavirus’ Spike Protein Attacks Vascular System on a Cellular Level (scitechdaily.com)

COVID-19 Is a Vascular Disease: Coronavirus’ Spike Protein Attacks Vascular System on a Cellular Level

Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease.

Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself.

The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies.

“A lot of people think of it as a respiratory disease, but it’s really a vascular disease,” says Assistant Research Professor Uri Manor, who is co-senior author of the study. “That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.”

Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others.

While the findings themselves aren’t entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. There’s been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented.

In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model—proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.

The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.

Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.

“If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.”

The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape.
 
printer

printer

Well-Known Member
Manitoba closure. One gem,

ORDER1919(1)All indoor recreational businesses, such as an escape room, trampoline park, laser tag facility, go-kart track, axe-throwing centre or climbing facility, must be closed while these Orders are in effect.

I did not know we had an axe throwing center never mind three of them. But I guess all those lawn bowlers don't have much to do when the snow is on the ground. Basically another 3 week closure, stores are limited to 10% capacity, no going over to visit friends. Hope people do as they are told otherwise it will stretch on.

Some statistics causing the closures.

20% cases school aged children, up 67%.
School staff cases up 25%,
Second highest rate in Canada five-day test positivity rate that rose to 13% variants now make up at least 38 per cent of Manitoba's active COVID-19 caseload
44 per cent of its adult population now partially immunized,
 
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S

schuylaar

Well-Known Member
DIY-HP-LED said:
This can explain a lot and perhaps some of the temporary effects of the vaccines. It also demonstrates that those who won't get vaccinated are playing with fire and long term maiming. Covid can screw you for live and this is one of the ways it does it.
----------------------------------------------------------------------------------------------------------------------------
COVID-19 Is a Vascular Disease: Coronavirus’ Spike Protein Attacks Vascular System on a Cellular Level (scitechdaily.com)

COVID-19 Is a Vascular Disease: Coronavirus’ Spike Protein Attacks Vascular System on a Cellular Level

Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease.

Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself.

The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies.

“A lot of people think of it as a respiratory disease, but it’s really a vascular disease,” says Assistant Research Professor Uri Manor, who is co-senior author of the study. “That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.”

Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others.

While the findings themselves aren’t entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. There’s been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented.

In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model—proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.

The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.

Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.

“If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.”

The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape.
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so i EM my specialist because Vacc sites want me to sign a waiver- 'well it does outweigh the risk' but then how come everyone else doesn't have to sign a waiver just me..like why do i have to be the guinea pig? that waiver says we have not tested it with people that are sick as you are so roll the dice if you wish but your family can't bring suit against us. i don't like that. but CBD/Weed is EVIL. that's because Big Pharma has no say except lobby:finger:

so men, i tried but i'm not signing away my families right to bring suit if they kill me..if this came in on emergency approval? then give it to those who've been trialed- it's unfair to shame a sick person because like they'd like to have what's rest of their life without exception. i will continue to mask up and socially distance. i don't even like it out there anymore, people are assholes..there are more travelers now and of course the tweeker traveler.
 
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schuylaar

Well-Known Member
DIY-HP-LED

DIY-HP-LED

Well-Known Member
schuylaar said:
so i EM my specialist because Vacc sites want me to sign a waiver- 'well it does outweigh the risk' but then how come everyone else doesn't have to sign a waiver just me..like why do i have to be the guinea pig? that waiver says we have not tested it with people that are sick as you are so roll the dice if you wish but your family can't bring suit against us. i don't like that. but CBD/Weed is EVIL. that's because Big Pharma has no say except lobby:finger:

so men, i tried but i'm not signing away my families right to bring suit if they kill me..if this came in on emergency approval? then give it to those who've been trialed- it's unfair to shame a sick person because like they'd like to have what's rest of their life without exception. i will continue to mask up and socially distance. i don't even like it out there anymore, people are assholes..there are more travelers now and of course the tweeker traveler.
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You're worried about your estate suing some vaccine manufacturer? The risks have been spelled out and if something happens, it won't be the fault of the manufacturer, that's just common sense. Perhaps the government should indemnify people for a million bucks, or cover the costs of vaccine reactions. There have been so few deaths, that it wouldn't have cost much at all paying out a million for each vaccine caused death or injury.

I hope you got vaccinated, there is not much of an excuse not to, very few health concerns warrant skipping it and not many doctors would recommend that you do.
 
DIY-HP-LED

DIY-HP-LED

Well-Known Member
captainmorgan said:
scitechdaily.com

82% of People Hospitalized With COVID-19 Develop Neurological Problems

Patients with clinically diagnosed neurological symptoms associated with COVID-19 are six times more likely to die in the hospital than those without the neurological complications, according to an interim analysis from the Global Consortium Study of Neurologic Dysfunction in COVID-19 (GCS-NeuroCOVI
scitechdaily.com
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Nightmares were common in people with fever and I wonder if this had anything to do with it. Large numbers of fucked up people are gonna be costly to the healthcare system, insurance premiums should go through the roof for everybody.

Once the mRNA vaccines come out of emergency use statues, insurance companies are gonna take a pretty dim view of the unvaccinated clowns. After the cutoff date, showing up at a hospital with covid will be plenty of proof you weren't vaccinated and are probably a fool as well. If they show up early in their illness, antibodies can help them, if they show up too late, it can be expensive and fatal.
 
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