I would keep the male's has far from the females has possible.Once the male plant starts to show it's time to shed it's pollen then get a large sealer bag and tap the dust from the male sack's into the bag.This can then be frozen and kept for some time i not sure how long but a good few month if not years.But if the strain is a plant that you realy like just clone it and take a extra female and let the male pollenate it.This will give you ample seeds for grow's to come.