Similar structured chemicals and their effects...

ever since being intrigued by what substances can do and their power to the human body and mind. along with the chemistry of both...

after observing the effects of certain substance's effects (similarities or differences) and reading about how they are chemically structured.
I have a question...

when chemicals that are structured similar to the other; can their effects be similar?

for example...
N,N-dimethyltryptamine (DMT)

4-phosphoryloxy-N,N-dimethyltryptamine (4-PO-DMT, Psilocybin [found in magic mushrooms])

4-hydroxy-N,N-dimethyltryptamine (4-HO-DMT, Psilocin [found in magic mushrooms])

the closed eye visuals that I receive under the influence of N,N-dimethyltryptamine (DMT, freebase smoke-able form) seem to be VERY similar to the closed eye visuals I get on psilocybin mushrooms. (of course, the N,N-dimethyltryptamine CEV are a lot more vivid. but I believe that the psilocybin/psilocin in magic mushroom's CEV can get just as vivid with a stronger dose...)


also....i've never truly "threshold" or "broken through" on n,n dmt.
i have of course felt its mild effects. i find them very pleasant.
I have read SEVERAL trip reports of users meeting, interacting, talking...ect to entities when "breaking through" after smoking n,n dmt...

after reading about the psychedelic experience trip levels on wiki...
(link: http://en.wikipedia.org/wiki/Psychedelic_experience )

it seems that level 5 can ONLY be experienced on tryptamines such as dmt, psilocybin, and psilocin.

i've never read a trip report of someone on a large dose of mushrooms meeting an entity or reaching true definitions of a level 5 trip. when it has never been achieved with any other chemical

would anyone like to chime in?

http://en.wikipedia.org/wiki/Structure-activity_relationship

Structure activity relationship or SAR in Pharmacology.

Its extremely complicated and Chemistry/Pharmacologists are trying to research into it.

I believe, that when it comes to Psychotropic substances, those that pass the blood brain barrier and start working on the cells in our brains it gets hell of alot more complicated and i think the bank of scientific knowledge in this field is still in its infancy, as with alot of neuroscience. Nerve cells in the brain can be connected to thousands of other nerve cells at points called synapses and if im correct its extremely complicated to give a clear-cut answer to it, because there is not one. Its all so multi-factoral. E.g testing one drugs and its effects by itself has many different problems along the way, e.g subjectivity of assessing a human participant (or animal) varies from researcher to researcher, aswell as that clincal studies in sterile environments lack mundane realism, also its about enzymes and the metabolic pathways of certain drugs - the metabolic products themselves can have psychotropic effects and its only theoretical but its incredible hard to measure quantities of chemicals in real-time in the brain. (without being extremely intrusive, this in itself can cause trauma to an animal and make it express unwanted charateristics and confound any results you get from a study)
I reccomend you get, a very short introduction to drugs. Its quite a nice little book but should be read with a little bit of predisposed biology and chemistry knowledge.