They are active on their own, but you need to gradualy increase doses to reach that point, the tannins are quite hard on the stomach.
You can look into useing eggwhite to seperate some tannins out if you just make tea, I think I suggested it to Schwag who has confirmed it worked.
I prefer extracting the harmaloids (I don't bother seperating them - it is easy though you pick which ones you want by adjusting pH), its pretty easy and you only need stuff like vinegar etc.
No diatary precautions are needed, it is not a MAOI it is a RIMA which is a reversable inhibitor.
What happens with MAOI complications (the real ones) is that certain enzymes that clear the body of toxins etc., literaly takes weeks to build up to optimal levels once desturbed with a proper inhibitor.
During that time your body can not break down certain metabolytes. It is called cheese syndrome if you want to look it up... (you get it from eating things like fermented cheeses).
Another good use for rue is when you start comming down from MDMA, it will repotentiate the shit out of what is left in your blood.