Best thing to do is spray it on away from your lights. Let it sit until plant is dry, or you will burn your plants. Its like putting sun tan lotion on your plant. I usually put a fan out to blow on the plant this helps the drying and knocks off some of the extra spray. plants will absorb it though like a foliage food. Depending on what brand you buy you might have to add a drop or two of dish detergent to help it stick. I only use Neem Oil as a preventive maintenance. Its not strong enough to kill off some type of molds, only holds them a bay for a while, same with the bugs. good preventive maintenance but not a good fix. And one last thing... Dont use it on buds!!! It will make them look shity, it will turn your hairs brown. If you do use on buds dont do it after the five week mark. Good luck.