I have been using a 1000w hps to flower for about a year. I started out using a 4" Vortex in line fan to cool a Sun Supply Yieldmaster II 6" glass covered hood. I necked down one 6" opening to the hood to connect the 4" fan. It worked just fine in my opinion my plants would get closer than 6" to the light and not suffer heat stress (althought this was because I let my plants height get away from me, I like to keep them about 1 foot minimum away from the light and 1.5 feet optimum distance just to maintain better coverage, ).
Ithen used a 6" Vortex to cool the same hood and it worked even better, although I feel it was not necessary.
I now use Sun Supply Magnum XXXL hood with 1000w hps and the 6" Vortex and its THE POO! I realized what a difference a nice hood can make, my yield and quality has increased dramatically from this one investment.
In short: 4" worked just fine for me to cool a 1000w light, but 6" worked even better
edit:
Looks like nickfury has the same magnum hood I do (the one with the air intake). My 6" fan also like nicks does more than just cool a single light, it also pulls air through a large carbon scrubber as well before exhausting.