I have been reading alot about sceletium and nootropics... very, very interesting products!
In my opinion its not a good mixture ANC. Mdma alone is neurotoxic at some levels especially if not in conjunction with antioxidants such as alpha lopoic acid, vitamin C & E. Mesembrine the main chemical contained in Kanna acts on two main nuerotransmitters dopamine and serontonin receptors as while as noradrenaline sites. It is best described as a mood-elevating supplement that provides a calming, tactile, and euphoric state at higher doses. The actions in themselves are very similar to mdma in the way that in smaller doses mdma provides a calm, sedative state. At higher doses it can be somewhat stimulating with a very euphoric taste. Both in combination can be more neurotoxic as it can potentiate domanergic actions, which may explain the reason why its such a good synergistic/potentiator of mdma. You say afterwards, the comedown or the following days after you feel a bit bummed out more than usual than a standard dose of ecstasy. That may be the reason why... because of oxidative stress! I am still debating whether or not I should mix the too... its a great catalyst! But if I do then their is no option to balance out all the free radicals and supplement with high dose antioxidants before, during, and after the roll to eliminate much of the stress. One of its key effects is to treat or diminish the effects of anxiety.... would it be a great tool to use after a mdma dose? This is one big debate and I am willing to give it a try... their is very little information on scelectium... and its benefits seem to outweigh the negative reactions compared to pharmaceutical serontonin-uptake inhibitors. Its indigigenious and practical... I might just order it.
ANC, do you have any remarkable feedback on this matter?