The larger the diameter the less the fan will have to work and the lower the noise (6" is preferable to 4"). I'd only go with a smaller diameter if space is really cramped - which it shouldn't be with the tent being 4' wide.
If you notice in my picture, my carbon filter came with a 6" to 4" reducer attached and I was just too lazy to remove it even though my ducting is 6"... technically I should have removed the reducer for maximum efficiency but... well you know, I'm a pothead.
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Oh and yeah you could support 4 plants under 400w inside of 2'X4' feet (if you aren't thinking of growing trees). I'm guessing you want to do four because you have four different strains? If so, take into account that some of those strains are sativa dominant and some are indica dominant so their widths, heights, nutrient requirements and flowering length/time are going to differ a lot which can lead to some minor headaches/hoops to jump through if being grown at the same time.
Hope you are planning on doing a grow journal? My first grow I did one on here (under a different name and through proxies for security) and got a lot of help from start to finish. The feedback really helped in making it a successful grow.
And I have to agree with bajafox - dealing with heat can be one of the most annoying aspects of growing indoors. It's one aspect you have to throw some money and thought into or else it will kill/retard your plants.