I feel that studies leave loose ends..there's no base panel...who's to say who needs more study or less or more drugs or placebo...all subjects should be subjected to the same tests and their data be compared to each other regarding a sober base standard..and then compared to other significant variables in the same respect...under various aspects,this could account for thousands of different settings for the medicinal use of drugs..alas,there is not an extra 1 million$s setting around for the long term and in depth studies...just the small amount of variables has the studies budgets stretched to paper thin...